Endocrine Abstracts

Giant cell tumors are rare, benign but aggressive and locally invasive tumors that usually affect the long bones in the limbs, typically presenting during the 3rd or 4th decade of life. Giant cell tumors of the skull are exceedingly rare, and less than 150 cases have been reported to date, of which less than 10 were described in the pediatric population. Here, we present the case of a 14 year old female that progressively developed severe headaches, blurr...

One of the clinical complications associated with the long term use of bisphosphonates treatment in osteoporosis is the atypical femoral fracture (AFF).Even the absolute risk is low and acceptable compared with the number of fractures prevented, there are still reasonable concerns due to the wide prescription of bisphosphonates and the existence of several case series proving that bisphosphonates have a strong association with this unique fracture type. We present a case of a ...

The secretion of adipocytokines is influenced by fat mass, but also by various situations related to acute stress (food deprivation, or critical state related to inflamatory or infectious syndromes). Adipocytokinic secretory profile could be therefore used for the diagnosis of the type of critical state, as well for the evolution and survival prognosis of patients. The modifications of adipocytokinic markers during the first hours after surgical intervention are insufficiently...

Transsphenoidal surgery still appears to be the best option for most of the patients with GH secreting adenomas. In many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Alternatives include medical therapy with somatostatin analogues, GH-receptor antagonists and dopamine agonists. These drugs can be used alone or in combination. Radiation therapy with conventional fractionated photons or radiosurgery with proton beam could also be eff...

Introduction: Somatostatin analogs, formerly used as adjuvants in acromegaly treatment, are widely used as primary treatment today.Objective: To investigate the efficacy of octreotide therapy in acromegalic patients as primary or secondary therapy.Materials and methods: Four acromegalic patients diagnosed at the Endocrinological Clinic (males, mean age 35–75 years, age range 26–49 years, all patients with macroadenoma) we...

Introduction: In Romania, the prevalence of postmenopausal osteoporosis in urban centers was estimated by a study in 2007 to be 16.5%. Using alendronate we are increasing bone mineral density and reducing bone turn-over in women with postmenopausal osteoporosis.Materials and methods: There were examined 55 postmenopausal women with osteoporosis (average age 62±4.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer ...

Aim: To evaluate the effect of risedronate vs ibandronate in treatment of systemic osteoporosis in postmenopausal women.Materials and methods: We examined 57 postmenopausal women with systemic osteoporosis (average age 61±3.5 years). Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometer (HOLOGIC Delphi W; SN 7044909) on lumbar spine. Examination was performed before the onset of treatment and after a period of 1, 2 and 3 year...

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

Introduction: Kabuki syndrome (KS) is a rare congenital, multisystemic disorder caused by pathogenic variants of KMT2D or KDM6A genes, causing autosomal dominant KS type 1 (more than 80%) and X-linked KS type 2 respectively. The phenotype spectrum is highly variable, consisting of a mixture of any of the five cardinal features (facial dysmorphic features, skeletal defects, dermatoglyphic abnormalities, various degrees of intellectual and growth retardation) with structural dis...

Adipose tissue performs an important endocrine role, mediated by hormones (adipocytokines) which are specifically secreted by the adipocytes. Epidemiological data consistently show an association between weight gain and the risk of colorectal cancer in adults.This observation led to the evaluation of a possible linking role of adipocytokines with cancer pathogenesis. There are several studies that associate adipocytokines with colorectal malignancy, but few data about patients...